Dimethylarginine Dimethylaminohydrolase Overexpression Enhances Insulin Sensitivity
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چکیده
منابع مشابه
Dimethylarginine dimethylaminohydrolase overexpression enhances insulin sensitivity.
OBJECTIVE Previous studies suggest that nitric oxide (NO) may modulate insulin-induced uptake of glucose in insulin-sensitive tissues. Asymmetrical dimethylarginine (ADMA) is an endogenous inhibitor of NO synthase (NOS). We hypothesized that a reduction in endogenous ADMA would increase NO synthesis and thereby enhance insulin sensitivity. METHODS AND RESULTS To test this hypothesis we used a...
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Johannes Jacobi, Karsten Sydow, Georges von Degenfeld, Ying Zhang, Hayan Dayoub, Bingyin Asymmetric Dimethylarginine Levels and Enhances Angiogenesis Overexpression of Dimethylarginine Dimethylaminohydrolase Reduces Tissue Print ISSN: 0009-7322. Online ISSN: 1524-4539 Copyright © 2005 American Heart Association, Inc. All rights reserved. is published by the American Heart Association, 7272 Gree...
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BACKGROUND This study was designed to determine whether overexpression of the enzyme dimethylarginine dimethylaminohydrolase (DDAH) could enhance angiogenesis by reducing levels of the endogenous nitric oxide synthase (NOS) inhibitor asymmetric dimethylarginine (ADMA). METHODS AND RESULTS In DDAH1 transgenic (TG) and wild-type mice (each n=42), the role of DDAH overexpression on angiogenesis ...
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BACKGROUND Graft coronary artery disease (GCAD) is the leading cause of death after the first year of heart transplantation. The reduced bioavailability of endothelium-derived nitric oxide (NO) may play a role in endothelial vasodilator dysfunction and the structural changes that are characteristic of GCAD. A potential contributor to endothelial pathobiology is asymmetric dimethylarginine (ADMA...
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EFFECT OF DIMETHYLARGININE DIMETHYLAMINOHYDROLASE IN TEDEVELOPMENT OF SALT SENSITIVITYbySAMAR ABDULLA NASSERMay 2011Advisor: Dr. John FlackMajor: PhysiologyDegree: Doctor of PhilosophySalt sensitivity is associated with a rise in blood pressure (BP) occurring duringsodium loading and/or a fall in BP during sodium restriction that exceeds randomfluctua...
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ژورنال
عنوان ژورنال: Arteriosclerosis, Thrombosis, and Vascular Biology
سال: 2008
ISSN: 1079-5642,1524-4636
DOI: 10.1161/atvbaha.108.162073